What frontend tech stack should I learn?

Hey PHers...so I am more of a old-school tech guy. Knows basic stack: Jquery, Javascript (older version), HTML, CSS, Bootstrap. And on backend it's Python, Django I keep on getting basic tech ideas. However, where I get stuck is how I can quickly build an MVP where the vanilla stack has today's look and feel - micro-interactions, fast loading etc. So thus was contemplating what front end stack should I pick which works for modern web and also easier to learn. (bonus: works well with Python and Django)